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Source: http://www.bbc.co.uk/news/health-18190352
Male pill: gene discovery may lead to contraceptive
Healthy sperm manufacture needs the Katnal1 gene
It may be possible to develop a new male contraceptive pill after researchers in Edinburgh identified a gene critical for the production of healthy sperm.
Experiments in mice found that the gene, Katnal1, was vital for the final stages of making sperm.
The authors of a study in PLos Genetics said a drug which interrupts Katnal1 could be a reversible contraceptive.
A fertility expert said there was "certainly a need" for such a drug.
Contraception in men is largely down to condoms or a vasectomy.
Infertility search
Researchers at the Centre for Reproductive Health at the University of Edinburgh were investigating the causes of male infertility.
They randomly altered the genetic code of mice to see which became infertile. They then traced the mutations which led to infertility, which led them to Katnal1.
Continue reading the main story
“Start Quote
Dr Lee Smith University of EdinburghIf we can find a way to target this gene in the testes, we could potentially develop a non-hormonal contraceptive”
It contains the blueprints for a protein which is important in cells which support the development of sperm. Without the protein, sperm do not fully form and the body disposes of them.
Scientists hope they will be able to perform a similar trick in humans to stop sperm developing, without causing lasting damage.
One of the researchers Dr Lee Smith said: "If we can find a way to target this gene in the testes, we could potentially develop a non-hormonal contraceptive.
"The important thing is that the effects of such a drug would be reversible because Katnal1 only affects sperm cells in the later stages of development, so it would not hinder the early stages of sperm production and the overall ability to produce sperm.
He said it would be "relatively difficult" to do as the protein lives inside cells, however, he said there was "potential" to find something else that protein worked with, which might be an easier target.
'Holy Grail'
Dr Allan Pacey, senior lecturer in andrology at the University of Sheffield, said there was "certainly a need" for a non-hormonal contraceptive for men and that this had been a "Holy Grail" of research for many years.
He added: "The key in developing a non-hormonal contraceptive for men is that the molecular target needs to be very specific for either sperm or other cells in the testicle which are involved in sperm production.
"If they are not, then such a contraceptive could have unwanted side effects on other cells and tissues in the body and may even be dangerous.
"The gene described by the research group in Edinburgh sounds like an exciting new possible target for a new male contraceptive, but it may also shed light on why some men are sub-fertile and why their sperm does not work properly."
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WARNING FROM RAEL: For those who don't use their intelligence at its full capacity, the label "selected by RAEL" on some articles does not mean that I agree with their content or support it. "Selected by RAEL" means that I believe it is important for the people of this planet to know about what people think or do, even when what they think or do is completely stupid and against our philosophy. When I selected articles in the past about stupid Christian fundamentalists in America praying for rain, I am sure no Rael-Science reader was stupid enough to believe that I was supporting praying to change the weather. So, when I select articles which are in favor of drugs, anti-semitic, anti-Jewish, racist, revisionist, or inciting hatred against any group or religion, or any other stupid article, it does not mean that I support them. It just means that it is important for all human beings to know about them. Common sense, which is usually very good among our readers, is good enough to understand that. When, like in the recent articles on drug decriminalization, it is necessary to make it clearer, I add a comment, which in this case was very clear: I support decriminalizing all drugs, as it is stupid to throw depressed and sad people (as only depressed and sad people use drugs) in prison and ruin their life with a criminal record. That does not mean that there is any change to the Message which says clearly that we must not use any drug except for medical purposes. The same applies to the freedom of expression which must be absolute. That does not mean again of course that I agree with anti-Jews, antisemites, racists of any kind or anti-Raelians. But by knowing your enemies or the enemies of your values, you are better equipped to fight them. With love and respect of course, and with the wonderful sentence of the French philosopher Voltaire in mind: "I disapprove of what you say, but I will defend to the death your right to say it".
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"Ethics" is simply a last-gasp attempt by deist conservatives and
orthodox dogmatics to keep humanity in ignorance and obscurantism,
through the well tried fermentation of fear, the fear of science and
new technologies.
There is nothing glorious about what our ancestors call history,
it is simply a succession of mistakes, intolerances and violations.
On the contrary, let us embrace Science and the new technologies
unfettered, for it is these which will liberate mankind from the
myth of god, and free us from our age old fears, from disease,
death and the sweat of labour.
Rael
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