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Source: http://www.telegraph.co.uk/science/science-news/9191848/Universal-cancer-vaccine-developed.html
'Universal' cancer vaccine developed
A vaccine that can train cancer patients' own bodies to seek out and destroy tumour cells has been developed by scientists.
The therapy, which targets a molecule found in 90 per cent of all cancers, could provide a universal injection that allows patients' immune systems to fight off common cancers including breast and prostate cancer.
Preliminary results from early clinical trials have shown the vaccine can trigger an immune response in patients and reduce levels of disease.
The scientists behind the vaccine now hope to conduct larger trials in patients to prove it can be effective against a range of different cancers.
They believe it could be used to combat small tumours if they are detected early enough or to help prevent the return and spread of disease in patients who have undergone other forms of treatment such as surgery.
Cancer cells usually evade patient's immune systems because they are not recognised as being a threat. While the immune system usually attacks foreign cells such as bacteria, tumours are formed of the patient's own cells that have malfunctioned.
Scientists have, however, found that a molecule called MUC1, which is found in high amounts on the surface of cancer cells, can be used to help the immune system detect tumours.
The new vaccine, developed by drug company Vaxil Biotheraputics along with researchers at Tel Aviv University, uses a small section of the molecule to prime the immune system so that it can identify and destroy cancer cells.
A statement from Vaxil Biotheraputics said: "ImMucin generated a robust and specific immune response in all patients which was observed after only 2-4 doses of the vaccine out of a maximum of 12 doses.
"In some of the patients, preliminary signs of clinical efficacy were observed."
The results are still to be formally published but if further trials prove to be successful the vaccine could be available within six years.
As a therapeutic vaccine it is designed to be given to patients who are already suffering from cancer to help their bodies fight off the disease rather than to prevent disease in the first place.
Cancer cells contain high levels of MUC1 as it is thought to be involved helping tumours grow. Healthy human cells also contain MUC1, but have levels that are too low to trigger the immune system after vaccination.
When a vaccinated patient's immune system encounters cancer cells, however, the far larger concentration of MUC1 causes it to attack and kill the tumour.
As MUC1 is found in 90 per cent of all cancers, the researchers believe it could be used to combat the growth and spread of a wide range of cancers.
In a safety trial at the Hadassah Medical Centre in Jerusalem, ten patients suffering from multiple myeloma, a form of blood cancer, have now received the vaccine.
Seven of the patients have now finished the treatment and Vaxil reported that all of them had greater immunity against cancer cells compared to before they were given the vaccine.
Vaxil added that three patients are now free of detectable cancer following the treatment.
The findings support research published in the journal Vaccine, which showed the treatment induced "potent" immunity in mice and increased their survival from cancer.
Cancer charities have given the vaccine a cautious welcome, but warned further testing was needed before it could be approved for widespread use.
There are currently a number of other therapeutic vaccines against cancer being tested, but they have met with limited success.
Dr Kat Arney, science information manager at Cancer Research UK, said: "There are several groups around the world investigating treatments that target MUC1, as it's a very interesting target involved in several types of cancer.
"These are very early results that are yet to be fully published, so there's a lot more work to be done to prove that this particular vaccine is safe and effective in cancer patients."
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WARNING FROM RAEL: For those who don't use their intelligence at its full capacity, the label "selected by RAEL" on some articles does not mean that I agree with their content or support it. "Selected by RAEL" means that I believe it is important for the people of this planet to know about what people think or do, even when what they think or do is completely stupid and against our philosophy. When I selected articles in the past about stupid Christian fundamentalists in America praying for rain, I am sure no Rael-Science reader was stupid enough to believe that I was supporting praying to change the weather. So, when I select articles which are in favor of drugs, anti-semitic, anti-Jewish, racist, revisionist, or inciting hatred against any group or religion, or any other stupid article, it does not mean that I support them. It just means that it is important for all human beings to know about them. Common sense, which is usually very good among our readers, is good enough to understand that. When, like in the recent articles on drug decriminalization, it is necessary to make it clearer, I add a comment, which in this case was very clear: I support decriminalizing all drugs, as it is stupid to throw depressed and sad people (as only depressed and sad people use drugs) in prison and ruin their life with a criminal record. That does not mean that there is any change to the Message which says clearly that we must not use any drug except for medical purposes. The same applies to the freedom of expression which must be absolute. That does not mean again of course that I agree with anti-Jews, antisemites, racists of any kind or anti-Raelians. But by knowing your enemies or the enemies of your values, you are better equipped to fight them. With love and respect of course, and with the wonderful sentence of the French philosopher Voltaire in mind: "I disapprove of what you say, but I will defend to the death your right to say it".
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"Ethics" is simply a last-gasp attempt by deist conservatives and
orthodox dogmatics to keep humanity in ignorance and obscurantism,
through the well tried fermentation of fear, the fear of science and
new technologies.
There is nothing glorious about what our ancestors call history,
it is simply a succession of mistakes, intolerances and violations.
On the contrary, let us embrace Science and the new technologies
unfettered, for it is these which will liberate mankind from the
myth of god, and free us from our age old fears, from disease,
death and the sweat of labour.
Rael
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